What does the research say about PANX3?

PANX3

There are 3 papers on PANX3 in aging research: none in people yet, 3 in animals. The newest story, Nov 6, 2026: “Mouse skeletal stem cells enter a shared, changeable state”.

Gene

3 papers study it6 findings

HGNC NCBI Gene Taxon

1 new paper in 30 daysSee all 3 papers on PANX3

At a glance

The findings reach mice, none yet in people. 2 independent labs in 1 country.

None of its findings points the other way.

2 independent labs in 1 country

Funder: Gouvernement du Canada | Canadian Institutes of Health Research

Animals3

Effects

Mortality

no changein mice1

1 study

PANX3 showed no clear effect on mortality in mice (shown by global knockout in aging mice).
“Global loss of Panx3 in aging mice was not associated with increased mortality”
Animalsshown by global knockout in aging mice
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice
Arthritis & rheumatology (Hoboken, N.J.)Jan 12, 2021

Appendicular skeleton length

upin mice1

1 study

PANX3 increases appendicular skeleton length in mice (shown by global knockout).
“Mice lacking Panx3 had shorter appendicular skeletons than WT mice”
Animalsshown by global knockoutappendicular skeleton
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice
Arthritis & rheumatology (Hoboken, N.J.)Jan 12, 2021

Synovitis

downin mice1

1 study

PANX3 protects against synovitis in mice (shown by global knockout).
“while promoting synovitis in 18-month-old mice”
Animalsshown by global knockoutsynovial tissue
Global Deletion of Pannexin 3 Resulting in Accelerated Development of Aging-Induced Osteoarthritis in Mice
Arthritis & rheumatology (Hoboken, N.J.)Jan 12, 2021

Associations

Functional skeletal stem cell state

mixedin mice1

1 study

PANX3 is associated with functional skeletal stem cell state in mice.
“we identify Pannexin-3 (Panx3) to mark a dynamic functional state within bona fide SSCs”
Animalsskeletal stem cell
Mouse skeletal stem cells enter a shared, changeable state
bioRxivNov 6, 2026Preprint

Latest

1 paper in 12 months

bioRxivNov 6

Mouse skeletal stem cells enter a shared, changeable state

Experiments in mice tracked how development, bone-building stimulation and injury affected a shared stem cell state.Experiments in mice tracked how development, bone-building stimulation and injury affected a shared stem cell state.

Preprint: mouse studyMechanisms