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old-biasedgenes

Gene

1 paper3 findings

Taxon

  • In silico1

Effects

2

Sequence conservation

downin silico1

1 study

  1. old-biasedgenes decrease sequence conservation in silico.

    “Old-biased genes are less conserved across most cell types analyzed in the lung, brain, liver, muscle, kidney, and skin”

    In silicolung, brain, liver, muscle, kidney, skin

    Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels

    Genome biology and evolution30 Sep 2025

  2. old-biasedgenes decrease sequence conservation in silico.

    “sequence conservation among old-biased genes (with higher expression in old vs. young adults) is weaker than among young-biased genes”

    In silico

    Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels

    Genome biology and evolution30 Sep 2025

More on Sequence conservation

Transcriptome conservation

downin silico1

1 study

  1. old-biasedgenes decrease transcriptome conservation in silico.

    “age-related decrease in transcriptome conservation is commonly found in ageing tissues of nonmammalian species, including nonmammalian vertebrates (chicken brain, killifish liver and skin) and invertebrates (fruit fly brain)”

    In silicobrain

    Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels

    Genome biology and evolution30 Sep 2025

More on Transcriptome conservation

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