Sequence conservation

1. old-biasedgenes decrease sequence conservation in silico.

   “Old-biased genes are less conserved across most cell types analyzed in the lung, brain, liver, muscle, kidney, and skin”

   In silicolung, brain, liver, muscle, kidney, skin

   Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels

   Genome biology and evolution·30 Sep 2025

2. old-biasedgenes decrease sequence conservation in silico.

   “sequence conservation among old-biased genes (with higher expression in old vs. young adults) is weaker than among young-biased genes”

   In silico

   Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels

   Genome biology and evolution·30 Sep 2025

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