NOTCH

2 papers study it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

32 independent labs in 12 countries
2 findings against

Funders: National Institutes of Health and others
2 of 43 findings with company ties

Animals1
Model organisms1

Upstream

bark

downin flies1

1 study

bark decreases NOTCH in flies.
“depletion of bark in progenitor cells reduced Notch activity, biasing differentiation toward the secretory lineage.”
Model organismsprogenitor cell-specific depletionintestine
The septate junction component bark beetle is required for Drosophila intestinal barrier function and homeostasis
iScienceMay 19, 2023