bark

1. bark is required for intestinal barrier integrity in flies.

   “Our data implicate Bark in EC maturation and maintenance of intestinal barrier integrity.”

   Model organismsintestine

   The septate junction component bark beetle is required for Drosophila intestinal barrier function and homeostasis

   iScience·May 19, 2023

1. bark decreases NOTCH in flies.

   “depletion of bark in progenitor cells reduced Notch activity, biasing differentiation toward the secretory lineage.”

   Model organismsprogenitor cell-specific depletionintestine

   The septate junction component bark beetle is required for Drosophila intestinal barrier function and homeostasis

   iScience·May 19, 2023

More on NOTCH

1. bark shortens lifespan in flies.

   “Depletion of bark from enterocytes in young flies led to hallmarks of intestinal aging and shortened lifespan”

   Model organismsenterocyte-specific depletionintestine

   The septate junction component bark beetle is required for Drosophila intestinal barrier function and homeostasis

   iScience·May 19, 2023