NDI1

1. NDI1 extends lifespan in flies.

   “rescues the behavioural and lifespan phenotypes caused by complex I deficiency”

   Model organismsin neuronal ND-75 knockdown flies

   Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

   PLoS genetics·Jul 3, 2023

2. NDI1 extends lifespan in flies.

   “rescues the behavioural and lifespan phenotypes caused by complex I deficiency.”

   Model organismsin neuronal ND-75 knockdown Drosophilaneurons

   Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiency

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 23, 2022Preprint

3. NDI1 extends lifespan in mice.

   “NDI1 expression was sufficient to dramatically prolong lifespan without significantly improving motor function in a mouse model of Leigh syndrome driven by the loss of NDUFS4”

   Animalsin Ndufs4 knockout mouse model of Leigh syndromebrain

   NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction

   Cell metabolism·Jun 22, 2020

1. NDI1 inhibits ER unfolded protein response in flies.

   “prevents UPR activation”

   Model organismsin neuronal ND-75 knockdown fliesbrain

   Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

   PLoS genetics·Jul 3, 2023

2. NDI1 inhibits ER unfolded protein response in flies.

   “prevents UPR activation”

   Model organismsin neuronal ND-75 knockdown Drosophilaneurons

   Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiency

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 23, 2022Preprint

More on ER unfolded protein response

1. NDI1 improves locomotor defects in flies.

   “rescues the behavioural and lifespan phenotypes caused by complex I deficiency”

   Model organismsin neuronal ND-75 knockdown flies

   Yeast NDI1 reconfigures neuronal metabolism and prevents the unfolded protein response in mitochondrial complex I deficiency

   PLoS genetics·Jul 3, 2023

1. NDI1 increases endoplasmic reticulum-mitochondria contacts in flies.

   “reinstates endoplasmic reticulum-mitochondria contacts”

   Model organismsin neuronal ND-75 knockdown Drosophilaneurons

   Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiency

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 23, 2022Preprint

1. NDI1 improves locomotor function in flies.

   “rescues the behavioural and lifespan phenotypes caused by complex I deficiency.”

   Model organismsin neuronal ND-75 knockdown Drosophilaneurons

   Yeast NDI1 expression prevents the unfolded protein response and reconfigures metabolism to restore neuronal function in mitochondrial complex I deficiency

   bioRxiv (Cold Spring Harbor Laboratory)·Sep 23, 2022Preprint

1. NDI1 inhibits tumorigenicity in human cells.

   “Expression of the alternative NADH dehydrogenase NDI1 raises NAD+/NADH ratio, enhances the activity of the NAD+-dependent deacetylase SIRT3 and interferes with tumorigenicity in neurofibromin-deficient cells.”

   Cellsin neurofibromin-deficient cells

   Tumor growth of neurofibromin-deficient cells is driven by decreased respiration and hampered by NAD⁺ and SIRT3

   Cell death and differentiation·Apr 7, 2022

1. NDI1 has no effect on motor function in mice.

   “without significantly improving motor function in a mouse model of Leigh syndrome driven by the loss of NDUFS4”

   Animalsin Ndufs4 knockout mouse model of Leigh syndromebrain

   NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction

   Cell metabolism·Jun 22, 2020