MTFR1L
1 paper4 findings
- 1 lab in 1 country
- Funders: Foundation for the National Institutes of Health and 6 more
- Animals1
Effects
4Cardiac dysfunction
downin mice1
1 study
Cardiac dysfunction
downin mice1
MTFR1L prevents cardiac dysfunction in mice.
“leading to accumulation of damaged mitochondria, increased inflammation and senescence, and accelerated age-related cardiac dysfunction.”
Animalsshown by knockoutheart
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Proceedings of the National Academy of Sciences of the United States of America23 Jan 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
MTFR1L prevents cellular senescence in mice.
“leading to accumulation of damaged mitochondria, increased inflammation and senescence, and accelerated age-related cardiac dysfunction.”
Animalsshown by knockoutheart
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Proceedings of the National Academy of Sciences of the United States of America23 Jan 2026
PRKN
upin mice1
1 study
PRKN
upin mice1
MTFR1L activates PRKN in mice.
“Genetic deletion of Mtfr1l in mice impairs stress-induced mitophagy and Parkin activation”
Animalsshown by knockoutheart
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Proceedings of the National Academy of Sciences of the United States of America23 Jan 2026
Mitophagy
upin mice1
1 study
Mitophagy
upin mice1
MTFR1L activates mitophagy in mice.
“Genetic deletion of Mtfr1l in mice impairs stress-induced mitophagy and Parkin activation”
Animalsshown by knockoutheart
MTFR1L is a cardiac antiaging factor for maintenance of mitochondrial homeostasis
Proceedings of the National Academy of Sciences of the United States of America23 Jan 2026