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MRE11A

There are 4 papers on MRE11A in aging research: 1 observational study in people, 3 in animals.

Gene

4 papers study it2 findings

HGNCNCBI GeneTaxon

See all 4 papers on MRE11A

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 4 more
  • Humans1
  • Animals3

Effects

2

Synovitis

downin mice1

1 study

  1. MRE11A decreases synovitis in human-synovium chimeric mice.

    “MRE11A reconstitution mitigated synovitis”

    Animalsin human-synovium chimeric micesynovium

    Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

    Immunity

More on Synovitis

Telomeric damage

downin human cells1

1 study

  1. MRE11A decreases telomeric damage in rheumatoid arthritis CD4+ T cells.

    “RA T cells had low expression of the double-strand-break repair nuclease MRE11A, leading to telomeric damage, juxtacentromeric heterochromatin unraveling, and senescence marker upregulation”

    Cellsin rheumatoid arthritis CD4+ T cells

    Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

    Immunity

More on Telomeric damage

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