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MIR-155-5P

There are 5 papers on MIR-155-5P in aging research: 2 observational studies in people, 3 in animals.

Gene

5 papers study it5 findings

See all 5 papers on MIR-155-5P

At a glance

The findings reach mice, none yet in people. 3 independent labs in 2 countries.

None of its findings points the other way.

Cells and mice: a single group. Worms or flies and humans: nothing yet.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 3 independent labs in 2 countries
  • Funders: American Heart Association and others
  • 2 of 5 findings with company ties
  • Humans2
  • Animals3

Effects

5

mTOR signaling pathway components

downin mice1

1 study

  1. MIR-155-5P inhibits mTOR signaling pathway components in mice.

    “and target mTOR signaling pathway components and other cellular communication pathways”

    Animals

    A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

    Nature communications

Brain expression with age

upin mice1

1 study

  1. MIR-155-5P increases brain expression with age in mice (sex-independent).

    “We identified three sex-independent brain aging microRNAs (miR-146a-5p, miR-155-5p, and miR-5100).”

    Animalssex-independentbrain

    A spatio-temporal brain miRNA expression atlas identifies sex-independent age-related microglial driven miR-155-5p increase

    Nature communications

More on Brain expression with age

SIRT1

downin cells1

1 study

  1. MIR-155-5P inhibits SIRT1 in cells (alcohol exposure).

    “miR-155-5p targets and inhibits SIRT1, promoting the expression of mitochondrial VDAC1”

    Cellsalcohol exposureliver

    Dihydromyricetin regulates the miR-155-5p/SIRT1/VDAC1 pathway to promote liver regeneration and improve alcohol-induced liver injury

    Phytomedicine : international journal of phytotherapy and phytopharmacology

More on SIRT1

CAB39

downin human cells1

1 study

  1. MIR-155-5P decreases CAB39 in human cells (via AMPK signaling).

    “miR-155-5p inhibited mitochondrial fission and increased mitochondrial fusion in MSCs via the AMPK signaling pathway, thereby resulting in cellular senescence by repressing the expression of Cab39”

    Cellsvia AMPK signalingmesenchymal stem cells

    miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

    Aging cell

More on CAB39

Cellular senescence

upin human cells1

1 study

  1. MIR-155-5P increases cellular senescence in human cells (upregulation in young MSCs; downregulation in aged MSCs).

    “Upregulation of miR-155-5p in YMSCs led to increased cellular senescence, whereas downregulation of miR-155-5p decreased AMSC senescence.”

    Cellsupregulation in young MSCs; downregulation in aged MSCsmesenchymal stem cells

    miR-155-5p inhibition rejuvenates aged mesenchymal stem cells and enhances cardioprotection following infarction

    Aging cell

More on Cellular senescence

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