METTL1
- 3 independent labs in 2 countries
- Funders: National Natural Science Foundation of China and 4 more
- Animals2
- Cells1
Effects
2Aging traits
downin mice1
1 study
Aging traits
downin mice1
METTL1 protects against aging traits in mice.
“Mettl1 depletion results in accelerated aging in mice.”
Animalsin mice
Dynamic tRNA modification landscapes reveal METTL1 in fibroblasts as a central regulator of aging
Science China. Life sciencesJun 24, 2026
Cellular senescence
downin mice1
1 study
Cellular senescence
downin mice1
METTL1 decreases cellular senescence in mice.
“Supplementation of METTL1 alleviated SiC NPs-induced cellular senescence in vitro and in vivo.”
AnimalsSiC NPs-induced cellular senescence
Journal of hazardous materialsJun 12, 2026
Upstream
1Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
Cellular senescence decreases METTL1 in cells.
“Mettl1/Wdr4 and m7G gradually diminish with senescence and aging.”
Cells
Perturbation of METTL1-mediated tRNA N⁷- methylguanosine modification induces senescence and aging
Nature communicationsJul 8, 2024
Latest
2 in 12 monthsScience China Life Sciences
Dynamic tRNA modification landscapes reveal METTL1 in fibroblasts as a central regulator of aging
Experiments in miceMechanisms
Journal of Hazardous Materials
N(7)-methylguanosine modification of mitochondrial tRNA-Trp drives myocardial injury induced by silicon carbide nanoparticles
Experiments in miceMitochondrion
Nature Communications
Perturbation of METTL1-mediated tRNA N⁷- methylguanosine modification induces senescence and aging
Experiments in cellsCellular senescence