MDM1

1. MDM1 increases sphingoid bases in yeast cells.

   “Lipidomic analyses revealed decreased sphingoid bases and altered ceramide composition in mdm1Δ cells.”

   CellsShown by MDM1 deletion

   Sphingolipid regulation by yeast Mdm1 supports adaptive remodeling of the methionine transporter Mup1

   Molecular biology of the cell·27 May 2026

More on Sphingoid bases

1. MDM1 increases intracellular amino acid abundance in yeast cells.

   “loss of Mdm1 causes persistent retention of Mup1 at the plasma membrane (PM), accompanied by reduced intracellular methionine and broad amino acid depletion.”

   CellsShown by MDM1 deletion during starvation

   Sphingolipid regulation by yeast Mdm1 supports adaptive remodeling of the methionine transporter Mup1

   Molecular biology of the cell·27 May 2026

More on Intracellular amino acid abundance

1. MDM1 decreases mup1 retention at the plasma membrane in yeast cells.

   “We found that loss of Mdm1 causes persistent retention of Mup1 at the plasma membrane (PM)”

   CellsShown by MDM1 deletion during starvation

   Sphingolipid regulation by yeast Mdm1 supports adaptive remodeling of the methionine transporter Mup1

   Molecular biology of the cell·27 May 2026