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manf-1

Gene

1 paper3 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Institute of Environmental Health Sciences and 2 more
  • Model organisms1

Effects

3

Neuronal survival

upin worms1

1 study

  1. manf-1 increases neuronal survival in worms.

    “Multiple transgenic strains overexpressing MANF-1 showed extended lifespan of animals, reduced protein aggregation, and improved neuronal survival.”

    Model organismsTransgenic strains overexpressing MANF-1neuron

    The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans

    Proceedings of the National Academy of Sciences of the United States of America17 Oct 2024

Protein aggregation

downin worms1

1 study

  1. manf-1 decreases protein aggregation in worms.

    “Multiple transgenic strains overexpressing MANF-1 showed extended lifespan of animals, reduced protein aggregation, and improved neuronal survival.”

    Model organismsTransgenic strains overexpressing MANF-1

    The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans

    Proceedings of the National Academy of Sciences of the United States of America17 Oct 2024

Lifespan

upin worms1

1 study

  1. manf-1 extends lifespan in worms.

    “Multiple transgenic strains overexpressing MANF-1 showed extended lifespan of animals, reduced protein aggregation, and improved neuronal survival.”

    Model organismsTransgenic strains overexpressing MANF-1

    The neurotrophic factor MANF regulates autophagy and lysosome function to promote proteostasis in Caenorhabditis elegans

    Proceedings of the National Academy of Sciences of the United States of America17 Oct 2024

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