Lys

1. Lys shorten lifespan in flies.

   “which was also observed in those flies experiencing ectopic lysozyme overexpression in enterocytes.”

   Model organismsectopic overexpression in enterocytesenterocytes

   A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expression

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 3, 2023Preprint

1. SIRT4 decreases Lys in flies.

   “One of the most notable effects was the strong induction of lysozyme gene expression in the intestine, which also translates into enhanced lysozyme activity.”

   Model organismsshown by defect / silencingintestine

   A mitochondrial sirtuin shapes the intestinal microbiota by controlling lysozyme expression

   bioRxiv (Cold Spring Harbor Laboratory)·Jun 3, 2023Preprint

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