AgingResearch.NewsJoin free

LONRF2

Gene

2 papers study it3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Japan Agency for Medical Research and Development and 3 more
  • Animals2

Effects

3

Neurite length

upin human cells1

1 study

  1. LONRF2 improves neurite length in human cells.

    “The shortening of neurites in MNs from patients with amyotrophic lateral sclerosis is rescued by ectopic expression of LONRF2.”

    Cellsin ALS patient-derived MNs

    LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits

    Nature aging

Motor neuron degeneration

downin mice1

1 study

  1. LONRF2 prevents motor neuron degeneration in mice.

    “Lonrf2-/- mice exhibit age-dependent TDP-43-mediated motor neuron (MN) degeneration and cerebellar ataxia.”

    Animalsin Lonrf2-/- mice

    LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits

    Nature aging

Cerebellar ataxia

downin mice1

1 study

  1. LONRF2 prevents cerebellar ataxia in mice.

    “Lonrf2-/- mice exhibit age-dependent TDP-43-mediated motor neuron (MN) degeneration and cerebellar ataxia.”

    Animalsin Lonrf2-/- mice

    LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits

    Nature aging

More on Cerebellar ataxia

Latest

Related