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LOC105378097

Gene

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Effects

3

Heart ageing

upin mice1

1 study

  1. LOC105378097 increases heart ageing in mice.

    “Improved heart ageing and mitophagy caused by Parkin overexpression were reversed by lncR-SMAL in mice.”

    Animalsin miceheart

    LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice

    Clinical and translational medicineJun 1, 2022

Mitophagy

downin mice1

1 study

  1. LOC105378097 inhibits mitophagy in mice.

    “inhibited the associated cardiomyocytes mitophagy by depressing Parkin protein level”

    Animalsin cardiomyocytesheart

    LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice

    Clinical and translational medicineJun 1, 2022

More on Mitophagy

Cardiac function

downin mice1

1 study

  1. LOC105378097 impairs cardiac function in mice.

    “Exogenously overexpression of lncRNA SMAL deteriorated cardiac function exactly as natural ageing”

    Animalsnatural ageingheart

    LncRNA LOC105378097 inhibits cardiac mitophagy in natural ageing mice

    Clinical and translational medicineJun 1, 2022

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