LbNOX

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funders: National Institute of General Medical Sciences and 2 more

Model organisms1

Effects

Sleep patterns

upin flies1

1 study

LbNOX improves sleep patterns in flies.
“LbNOX expression in nonneuronal tissues restored youthful sleep patterns in aged flies”
Model organismsnonneuronal tissues
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes
Science advances2 Jan 2026

Oxidative stress and ROS signalling

downin flies1

1 study

LbNOX protects against oxidative stress and ROS signalling in flies.
“Muscle-specific LbNOX expression confers stronger protection against paraquat-induced oxidative stress than whole-body expression”
Model organismsparaquat-induced oxidative stressskeletal muscle
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes
Science advances2 Jan 2026

More on Oxidative stress and ROS signalling

Cell death

downin flies1

1 study

LbNOX decreases cell death in flies.
“rescued neuronal cell death induced by mutant αB-crystallin-associated reductive stress”
Model organismsin mutant αB-crystallin-associated reductive stressneuron
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes
Science advances2 Jan 2026

Lifespan

upin flies1

1 study

LbNOX extends lifespan in flies.
“Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes”
Model organisms
Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes
Science advances2 Jan 2026

Latest

1 in 12 months

Science Advances2 Jan

Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes

Experiments in fliesNAD+ metabolism

Paper

LbNOX

Effects

Latest

Perturbation of NAD(P)H metabolism with the LbNOX xenotopic tool extends lifespan and mitigates age-related changes

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