LamCmutations

1. LamCmutations impair jumping and flight performance in flies.

   “Consistent with these observations, the mutants had progressive jumping and flight defects.”

   Model organismsPS-modeled LamC mutations

   Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding

   Current biology : CB·Jul 21, 2016

1. LamCmutations increase myofibril disorganization in flies.

   “including a progressive accumulation of polyubiquitin aggregates [6, 7] and myofibril disorganization [8, 9].”

   Model organismsPS-modeled LamC mutations

   Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding

   Current biology : CB·Jul 21, 2016

1. LamCmutations increase polyubiquitin aggregates in flies.

   “PS-modeled LamC mutations also induced the accelerated appearance of other phenotypes associated with aging, including a progressive accumulation of polyubiquitin aggregates”

   Model organismsPS-modeled LamC mutations

   Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding

   Current biology : CB·Jul 21, 2016

More on Polyubiquitin aggregates

1. LamCmutations increase mitochondrial degradation in flies.

   “PS-modeled LamC mutations induced premature aging in adult flight muscles, including decreased levels of specific mitochondrial protein transcripts (RNA) and progressive mitochondrial degradation.”

   Model organismsPS-modeled LamC mutationsflight muscle

   Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding

   Current biology : CB·Jul 21, 2016

1. LamCmutations decrease mitochondrial protein transcripts in flies.

   “PS-modeled LamC mutations induced premature aging in adult flight muscles, including decreased levels of specific mitochondrial protein transcripts (RNA) and progressive mitochondrial degradation.”

   Model organismsPS-modeled LamC mutationsflight muscle

   Lamin Mutations Accelerate Aging via Defective Export of Mitochondrial mRNAs through Nuclear Envelope Budding

   Current biology : CB·Jul 21, 2016

More on Mitochondrial protein transcripts