AgingResearch.NewsJoin free

LamC

Gene

2 papers study it2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Achievement Rewards for College Scientists Foundation and others
  • Model organisms2

Effects

2

Cardiac decline

downin flies1

1 study

  1. LamC prevents cardiac decline in flies.

    “maintenance of Lamin C, and cardiac transcription factor expression, prevents age-dependent cardiac decline.”

    Model organismsmaintenance of expressionheart

    Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

    Nature aging

Heart contractility

downin flies1

1 study

  1. LamC decreases heart contractility in flies.

    “Premature genetic reduction of Lamin C phenocopies aging's effects on the nucleus, and subsequently decreases heart contractility and sarcomere organization.”

    Model organismspremature genetic reductionheart

    Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs

    Nature aging

Latest

Related