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KLC1

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 2 more
  • Humans1

Effects

2

PI3K–AKT signalling

upin mouse cells1

1 study

  1. KLC1 activates PI3K–AKT signalling in mouse cells.

    “Klc1 promotes AKT-mTOR activity and positively regulates myogenic differentiation.”

    Cellsgain- and loss-of-function experiments

    Kinesin light chain 1 stabilizes insulin receptor substrate 1 to regulate the IGF-1-AKT signaling pathway during myoblast differentiation

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 Feb 2024

More on PI3K–AKT signalling

Myoblast differentiation

upin mouse cells1

1 study

  1. KLC1 improves myoblast differentiation in mouse cells.

    “Gain- and loss-of-function experiments further displayed that Klc1 promotes AKT-mTOR activity and positively regulates myogenic differentiation.”

    Cellsgain- and loss-of-function experiments

    Kinesin light chain 1 stabilizes insulin receptor substrate 1 to regulate the IGF-1-AKT signaling pathway during myoblast differentiation

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology1 Feb 2024

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