IRF8

Gene3 papers1 finding

Humans1
Animals1

Upstream

1

STAT3

downin humans1

1 study

STAT3 inhibits IRF8 in humans.
Reviewproposed mechanism in review
A proposed convergent molecular chain linking senescence, cancer, and chronic infection to a correctable failure of dendritic cell instruction · Frontiers in immunology · 31 Jul 2026

Latest

3

Redox BiologyAnimals15 Sep

Age-related IGF-1 decline permits a redox-sensitive transcriptional shift that directs hematopoiesis toward a CCR2⁺ myeloid fate

Blood and immune system

Frontiers in ImmunologyReview28 Aug

A proposed convergent molecular chain linking senescence, cancer, and chronic infection to a correctable failure of dendritic cell instruction

BiomedicinesHumans27 Aug

Identification of Progressive Islet Biomarkers for Type 2 Diabetes by Integrated Transcriptomics and Mendelian Randomization: Alterations Spanning the Normal Glucose Tolerance-Impaired Glucose Tolerance-Type 2 Diabetes Continuum

Type 2 diabetes