aop

aop is required for lifespan in flies.

“activates the ETS-family repressor Aop/ETV6 downstream of Ras-Erk signaling, which is required for Dilp6 induction and the lifespan extension observed upon miR-8 depletion.”

Model organismsfor Dilp6 induction and lifespan extension upon miR-8 depletion

Adipose Dicer-1 modulates systemic insulin signaling and longevity via a miR-8-Aop-Dilp6 axis

Proceedings of the National Academy of Sciences of the United States of America·24 Mar 2026