There are 2 papers on ILF2 in aging research: 1 observational study in people.
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funder: Natural Science Foundation of Anhui Province
- Humans1
- In silico1
Effects
4Wound healing
upin mice1
1 study
Wound healing
upin mice1
ILF2 improves wound healing in mice (Diabetic mouse model; shown by ILF2 overexpression and knockdown).
“In vivo, ILF2 overexpression accelerated wound healing, while knockdown delayed the process.”
AnimalsDiabetic mouse model; shown by ILF2 overexpression and knockdownwound
Burns & trauma
NPM1 mRNA degradation
upin cells1
1 study
NPM1 mRNA degradation
upin cells1
ILF2 increases NPM1 mRNA degradation in cells.
“Mechanistically, ILF2 directly bound to nucleophosmin (NPM1) mRNA to promote its degradation.”
Cellsfibroblast
Burns & trauma
Cellular senescence
downin cells1
1 study
Cellular senescence
downin cells1
ILF2 decreases cellular senescence in cells (High-glucose-treated fibroblasts; shown by ILF2 knockdown).
“Functionally, ILF2 overexpression promoted fibroblast proliferation and migration while suppressing SASP, whereas knockdown exacerbated senescence.”
CellsHigh-glucose-treated fibroblasts; shown by ILF2 knockdownfibroblast
Burns & trauma
Senescence-associated secretory phenotype (SASP)
downin cells1
1 study
Senescence-associated secretory phenotype (SASP)
downin cells1
ILF2 decreases senescence-associated secretory phenotype (SASP) in cells (High-glucose-treated fibroblasts; shown by ILF2 overexpression).
“Functionally, ILF2 overexpression promoted fibroblast proliferation and migration while suppressing SASP, whereas knockdown exacerbated senescence.”
CellsHigh-glucose-treated fibroblasts; shown by ILF2 overexpressionfibroblast
Burns & trauma