There are 2 papers on Gp93 in aging research: none in people yet, 2 in animals.
At a glance
The findings reach worms or flies, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Fundamental Research Funds for the Central Universities and 4 more
- Model organisms2
Effects
3Oxidative stress and ROS signaling
downin flies1
1 study
Oxidative stress and ROS signaling
downin flies1
Gp93 decreases oxidative stress and ROS signaling in flies (paraquat exposure or aging).
“overexpression of Gp93 effectively curtails oxidative stress and neurodegeneration caused by paraquat exposure or the aging process”
Model organismsparaquat exposure or aging
Gp93 safeguards tissue homeostasis by preventing ROS-JNK-mediated apoptosis
Redox biology
Neurodegenerative disease
downin flies1
1 study
Neurodegenerative disease
downin flies1
Gp93 prevents neurodegenerative disease in flies (neuro-specific depletion).
“neuro-specific depletion of Gp93 results in ROS-JNK-mediated neurodegeneration”
Model organismsneuro-specific depletionneuron
Gp93 safeguards tissue homeostasis by preventing ROS-JNK-mediated apoptosis
Redox biology
Apoptosis
downin flies1
1 study
Apoptosis
downin flies1
Gp93 prevents apoptosis in flies (loss of Gp93).
“loss of Gp93 induces JNK-dependent apoptosis primarily through the induction of ROS”
Model organismsloss of Gp93
Gp93 safeguards tissue homeostasis by preventing ROS-JNK-mediated apoptosis
Redox biology