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GIT2

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Effects

3

Stem cell differentiation

upin mouse cells1

1 study

  1. GIT2 increases stem cell differentiation in mouse cells.

    “inhibit their activation, improve DNA damage repair, alleviate cell senescence, and further promote osteogenic differentiation of BMSCs.”

    Cells

    GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs

    Tissue & cell11 Feb 2025

More on Stem cell differentiation

Cellular senescence

downin mouse cells1

1 study

  1. GIT2 decreases cellular senescence in mouse cells.

    “inhibit their activation, improve DNA damage repair, alleviate cell senescence, and further promote osteogenic differentiation of BMSCs.”

    Cells

    GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs

    Tissue & cell11 Feb 2025

More on Cellular senescence

NF-κB signalling

downin mouse cells1

1 study

  1. GIT2 inhibits NF-κB signalling in mouse cells.

    “GIT2 could inhibit the activation of both canonical and non-canonical NF-κB signaling pathways by positively regulating TRAF3.”

    Cells

    GIT2 negatively regulates the NF-κB pathway directly or indirectly by regulating TRAF3 expression to promote osteogenic differentiation of BMSCs

    Tissue & cell11 Feb 2025

More on NF-κB signalling

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