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FASL

Gene

5 papers3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 3 independent labs in 2 countries
  • Funders: Chinese Academy of Sciences and others
  • Animals5

Interventions

1

Caloric restriction

upin mice1

1 study

  1. Caloric restriction increases FASL in mice.

    “Similarly, Fas-ligand (Fas-L) expression was higher in anti-CD3-stimulated CD4+ and CD8+ T cells.”

    Animalsin anti-CD3-stimulated CD4+ and CD8+ T cellsspleen6 monthsmales

    Calorie restriction increases Fas/Fas-ligand expression and apoptosis in murine splenic lymphocytes

    FEBS letters17 Sep 1999

More on Caloric restriction

Effects

2

Apoptosis

upin mice1

1 study

  1. FASL increases apoptosis in mice.

    “sequentially regulating catabolic metabolism through Fas ligand (FasL)-induced osteoclastic apoptosis.”

    Animalsin osteoclastsalveolar bonefemales

    Occlusal force orchestrates alveolar bone homeostasis via Piezo1 in female mice

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research24 May 2024

More on Apoptosis

Osteoclast numbers

upin mice1

1 study

  1. FASL increases osteoclast numbers in mice.

    “Gld mice, which have a Fas ligand mutation, have a slight yet insignificant decrease in bone mineral density, but a highly significant increase in osteoclast number.”

    AnimalsFas ligand mutation (Gld)

    Osteoclast apoptosis: the role of Fas in vivo and in vitro

    Endocrinology22 Aug 2003

More on Osteoclast numbers

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