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EST2

Gene

1 paper3 findings

Taxon 4932

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funder: National Institute on Aging
  • Cells1

Effects

3

Telomeric DNA extension

is required forin yeast cells1

1 study

  1. EST2 is required for telomeric DNA extension in yeast cells.

    “In vitro telomeric DNA extension occurred with extracts from wild-type yeast but not from est2 mutants or mutants deficient in telomerase RNA”

    Cellsin vitro extract assay

    Reverse transcriptase motifs in the catalytic subunit of telomerase

    Science (New York, N.Y.)25 Apr 1997

Cellular senescence

upin yeast cells1

1 study

  1. EST2 induces cellular senescence in yeast cells.

    “Introduction of single amino acid substitutions within the reverse transcriptase motifs of Est2 protein led to telomere shortening and senescence in yeast”

    Cellssingle amino acid substitutions within the reverse transcriptase motifs of Est2 protein

    Reverse transcriptase motifs in the catalytic subunit of telomerase

    Science (New York, N.Y.)25 Apr 1997

More on Cellular senescence

Telomere length

downin yeast cells1

1 study

  1. EST2 decreases telomere length in yeast cells.

    “Introduction of single amino acid substitutions within the reverse transcriptase motifs of Est2 protein led to telomere shortening and senescence in yeast”

    Cellssingle amino acid substitutions within the reverse transcriptase motifs of Est2 protein

    Reverse transcriptase motifs in the catalytic subunit of telomerase

    Science (New York, N.Y.)25 Apr 1997

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