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Duox

Gene

3 papers study it2 findings

Taxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Research Foundation of Korea
  • Model organisms3

Effects

2

Oxidative stress and ROS signaling

upin flies1

1 study

  1. Duox increases oxidative stress and ROS signaling in flies.

    “Neuronal knockdown experiments further suggested that duox is crucial to oxidative stress in neurons.”

    Model organismsneurons

    Dual Oxidase, a Hydrogen-Peroxide-Producing Enzyme, Regulates Neuronal Oxidative Damage and Animal Lifespan in Drosophila melanogaster

    CellsJun 29, 2022

More on Oxidative stress and ROS signaling

Lifespan

downin flies1

1 study

  1. Duox shortens lifespan in flies.

    “We found that duox heterozygous male flies, which were isogenized with control flies, demonstrated extended lifespan.”

    Model organismsmales

    Dual Oxidase, a Hydrogen-Peroxide-Producing Enzyme, Regulates Neuronal Oxidative Damage and Animal Lifespan in Drosophila melanogaster

    CellsJun 29, 2022

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