DNA2

2 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 2 countries

Funders: Arcadia Fund and 5 more

Model organisms1
Cells1

Effects

Replication stress sensitivity

downin flies1

1 study

DNA2 protects against replication stress sensitivity in flies.
“Dna2 mutants demonstrated significant sensitivity to replication stress induced by MMS, hydroxyurea, topotecan, and nitrogen mustard.”
Model organismsin Dna2 mutants
Dna2 Responds to Endogenous and Exogenous Replication Stress in Drosophila melanogaster
Genes25 Sep 2025

Lifespan

no changein flies1

1 study

DNA2 has no effect on lifespan in flies.
“Adult lifespan was not reduced in Dna2 mutants, implying potential compensatory stress-response mechanisms.”
Model organismsin Dna2 mutants
Dna2 Responds to Endogenous and Exogenous Replication Stress in Drosophila melanogaster
Genes25 Sep 2025

Cellular senescence

downin human cells1

1 study

DNA2 prevents cellular senescence in human cells.
“DNA2 deprivation triggers the DNA damage checkpoint and invariably leads to ATR-p21-dependent cell-cycle exit before mitosis.”
Cellsupon degradation of DNA2
DNA2 enables growth by restricting recombination-restarted replication
Nature3 Sep 2025