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CXXC1

Gene

3 papers study it2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Includes the processes named after it and trials of drugs aimed at it.

  • 2 independent labs in 1 country
  • Funders: Key Research and Development Program of Zhejiang Province and 1 more
  • Animals3

Effects

2

Cellular homeostasis

is required forin mice1

1 study

  1. CXXC1 is required for cellular homeostasis in mice.

    “Disruption of Cxxc finger protein 1 (Cxxc1) activity, a key subunit of H3K4 methyltransferase, in ILC3s led to similar aging-related phenotypes.”

    AnimalsCxxc1 deficiencygut

    Cxxc finger protein 1 maintains homeostasis and function of intestinal group 3 innate lymphoid cells with aging

    Nature agingJul 10, 2023

More on Cellular homeostasis

maternal mRNA degradation

is required forin mice1

1 study

  1. CXXC1 is required for maternal mRNA degradation in mice.

    “Oocyte-specific knockout of the gene encoding CxxC-finger protein 1 (CXXC1), a DNA-binding subunit of SETD1 methyltransferase, causes ooplasm changes associated with accelerated aging and impaired maternal mRNA translation and degradation.”

    Animalsoocyte-specific knockoutoocytefemales

    Dynamic mRNA degradome analyses indicate a role of histone H3K4 trimethylation in association with meiosis-coupled mRNA decay in oocyte aging

    Nature communicationsJun 9, 2022

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