COPS8

1. COPS8 increases HIF1A in human cells.

   “CSN8 enhanced HIF-1α protein expression and suppressed Skp2 and p21 expression through inhibiting HIF-1α ubiquitination”

   Cellsunder hypoxia

   Upregulation of CSN8 induces a unique senescence-like state with robust tumor-promoting properties in epithelial ovarian cancer cells under hypoxia

   Journal of translational medicine·18 Apr 2026

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1. COPS8 induces cellular senescence in human cells.

   “CSN8-overexpressed EOC cells exhibit senescence-like features (increased SA-β-gal activity, p16 expression, and SASP production) and robust tumor-promoting properties.”

   Cellsin EOC cells under hypoxia

   Upregulation of CSN8 induces a unique senescence-like state with robust tumor-promoting properties in epithelial ovarian cancer cells under hypoxia

   Journal of translational medicine·18 Apr 2026

More on Cellular senescence