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CG8004

Gene

1 paper3 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Model organisms1

Effects

3

Mitochondrial fragmentation

downin flies1

1 study

  1. CG8004 decreases mitochondrial fragmentation in flies.

    “The absence of CG8004 also leads to mitochondrial fragmentation within GRN axons”

    Model organismsshown by loss of CG8004gustatory receptor neuron axon

    Metaxin-2 tunes mitochondrial transportation and neuronal function in Drosophila

    Genetics15 Dec 2024

Mitochondrial quantity in axon terminals

upin flies1

1 study

  1. CG8004 increases mitochondrial quantity in axon terminals in flies.

    “Conditional knockout of CG8004 in adult gustatory receptor neurons (GRNs) impairs mitochondrial trafficking along GRN axons and diminishes the mitochondrial quantities in axon terminals.”

    Model organismsshown by conditional knockout of CG8004gustatory receptor neuron axon terminal

    Metaxin-2 tunes mitochondrial transportation and neuronal function in Drosophila

    Genetics15 Dec 2024

More on Mitochondrial quantity in axon terminals

Axonal mitochondrial trafficking

upin flies1

1 study

  1. CG8004 increases axonal mitochondrial trafficking in flies.

    “Conditional knockout of CG8004 in adult gustatory receptor neurons (GRNs) impairs mitochondrial trafficking along GRN axons and diminishes the mitochondrial quantities in axon terminals.”

    Model organismsshown by conditional knockout of CG8004gustatory receptor neuron axon

    Metaxin-2 tunes mitochondrial transportation and neuronal function in Drosophila

    Genetics15 Dec 2024

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