CFP

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 1 country

Funders: Science and Technology Development Fund and 2 more

Humans2
Animals1

Interventions

Amln diet

downin mice1

1 study

Amln diet decreases CFP in mice.
“CFP (encoding properdin), a macromolecular regulatory protein, was identified as a senescence marker that is highly expressed in LSECs and is downregulated in a stage-dependent manner during MASH-fibrosis.”
AnimalsMASH-fibrosisliver30 weeks
The CFP macromolecule attenuates senescent liver sinusoidal endothelial cell-driven activation of hepatic stellate cells
International journal of biological macromolecules14 Feb 2026

Effects

TGF-beta 1

downin mouse cells1

1 study

CFP decreases TGF-beta 1 in mouse cells.
“CFP knockdown (si-CFP) further exacerbated senescence and increased TGF-β1 secretion, whereas CFP overexpression (CFP-OE) effectively alleviated these effects.”
Cellsliver
The CFP macromolecule attenuates senescent liver sinusoidal endothelial cell-driven activation of hepatic stellate cells
International journal of biological macromolecules14 Feb 2026

Associations

Diabetes

upin humans1

1 study

CFP raises the risk of diabetes in humans (HRint=1.28, P=2.2E-6).
“complement factor P (CFP) interacted with rs7412-T (HRint=1.28, P=2.2E-6, and carriers had higher diabetes risk (HR=1.46, P=4.8E-14) than non-carriers (HR=1.15, P=2.1E-19).”
Humansrs7412-T carriers vs non-carriersn = 38,618
Proteome-Wide Interaction Study of Circulating Proteins with APOE ε4 Genotypes for Diabetes Risk—A Prospective Cohort Study
ADA Scientific Sessions 2025 abstract13 Jun 2025