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cebp-2

Gene

2 papers2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 2 countries
  • Funders: National Institute on Aging and 7 more
  • Animals2

Effects

1

Lifespan

downin worms2

2 studies

  1. cebp-2 shortens lifespan in worms.

    “Overexpression of the C. elegans C/EBPβ ortholog cebp-2 in neurons shortens lifespan and decreases NAD+ levels”

    Model organismsneuronal overexpression

    Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)30 Apr 2025

  2. cebp-2 shortens lifespan in worms.

    “Overexpression of CEBP-2 or LGMN-1 (AEP) in Caenorhabditis elegans neurons but not muscle stimulates neural excitation and shortens life span.”

    Model organismsneurons

    Neuronal C/EBPβ/AEP pathway shortens life span via selective GABAnergic neuronal degeneration by FOXO repression

    Science advances30 Mar 2022

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