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CAR4

Gene

1 paper3 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: Astellas Pharma and others
  • Animals1

Effects

3

Susceptibility to reactive oxygen species

downin mouse cells1

1 study

  1. CAR4 decreases susceptibility to reactive oxygen species in mouse cells.

    “Car4 KD cells demonstrated reduced expression of genes in the glutathione pathway and increased susceptibility to reactive oxygen species (ROS)”

    Cellsshown by Car4 knockdownadipocyte progenitor cell

    Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism

    Scientific reports29 Aug 2025

Glutathione pathway gene expression

upin mouse cells1

1 study

  1. CAR4 increases glutathione pathway gene expression in mouse cells.

    “Car4 KD cells demonstrated reduced expression of genes in the glutathione pathway”

    Cellsshown by Car4 knockdownadipocyte progenitor cell

    Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism

    Scientific reports29 Aug 2025

More on Glutathione pathway gene expression

Beige adipocyte differentiation

upin mouse cells1

1 study

  1. CAR4 increases beige adipocyte differentiation in mouse cells.

    “Car4 knockdown (KD) mitigated intracellular pH reduction and significantly suppressed beige adipocyte differentiation.”

    Cellsshown by Car4 knockdownadipocyte progenitor cell

    Car4-positive adipocyte progenitor cells adapt to the aging environment and work as protection against ROS via glutathione metabolism

    Scientific reports29 Aug 2025

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