bro1

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

1 lab in 1 country

Funder: NIHR Great Ormond Street Hospital Biomedical Research Centre

Cells1

Effects

Plasma membrane hexose transporter turnover

upin fission yeast cells1

1 study

bro1 increases plasma membrane hexose transporter turnover in fission yeast cells.
“Bro1 promotes TOR-dependent cargo deubiquitination, vacuolar trafficking, and turnover of plasma membrane hexose transporters”
CellsTOR-dependent
Bro1-Mediated Trafficking Couples TOR Signalling to Cellular Metabolism and Longevity
bioRxiv (Cold Spring Harbor Laboratory)12 Jan 2026Preprint

cargo deubiquitination

upin fission yeast cells1

1 study

bro1 increases cargo deubiquitination in fission yeast cells.
“Mechanistically, Bro1 promotes TOR-dependent cargo deubiquitination”
CellsTOR-dependent
Bro1-Mediated Trafficking Couples TOR Signalling to Cellular Metabolism and Longevity
bioRxiv (Cold Spring Harbor Laboratory)12 Jan 2026Preprint

Global proteomic reprogramming

is required forin fission yeast cells1

1 study

bro1 is required for global proteomic reprogramming in fission yeast cells.
“Bro1 is required for normal lifespan and for the global proteomic reprogramming that accompanies TOR inhibition.”
Cellsduring TOR inhibition
Bro1-Mediated Trafficking Couples TOR Signalling to Cellular Metabolism and Longevity
bioRxiv (Cold Spring Harbor Laboratory)12 Jan 2026Preprint

Lifespan

is required forin fission yeast cells1

1 study

bro1 is required for lifespan in fission yeast cells.
“Using fission yeast, we show that Bro1 is required for normal lifespan”
Cellsshown by absence of Bro1
Bro1-Mediated Trafficking Couples TOR Signalling to Cellular Metabolism and Longevity
bioRxiv (Cold Spring Harbor Laboratory)12 Jan 2026Preprint

Latest

1 in 12 months

bioRxiv12 Jan

Bro1-Mediated Trafficking Couples TOR Signalling to Cellular Metabolism and Longevity

Preprint: experiments in yeastmTOR signalling

Paper

bro1

Effects

Latest

Bro1-Mediated Trafficking Couples TOR Signalling to Cellular Metabolism and Longevity

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