BMP1

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs

Humans1
Cells1

Interventions

Resistance training

upin humans1

1 study

Resistance training increases BMP1 in humans.
“A meta-analysis of public muscle transcriptomes showed that resistance training increases BMP1 expression.”
Humansskeletal muscle
Epigenetic signatures and genetic variants associated with muscle strength in postmenopausal women: potential bone muscle cross talk via BMP1 mechanisms
Physiological genomics3 Feb 2026

Effects

Fibril orientation disturbance

downin human cells1

1 study

BMP1 prevents fibril orientation disturbance in human cells.
“BMP-1 knockdown in cells of early PDLs decreased the amount of extracellular collagen and disturbed the fibril orientation.”
Cellsshown by knockdown in early PDL cellsskin
Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP-1
Genes to cells : devoted to molecular & cellular mechanisms21 Feb 2026

Extracellular collagen

upin human cells1

1 study

BMP1 increases extracellular collagen in human cells.
“BMP-1 knockdown in cells of early PDLs decreased the amount of extracellular collagen and disturbed the fibril orientation.”
Cellsshown by knockdown in early PDL cellsskin
Senescence in Normal Human Dermal Fibroblasts Induces Heterogeneous Fibril Orientation of Type I Collagen Through Downregulation of BMP-1
Genes to cells : devoted to molecular & cellular mechanisms21 Feb 2026