BARD1

There are 9 papers on BARD1 in aging research: 1 trial and 4 observational studies in people, 1 in animals, 2 in cells.

9 papers study it2 findings

HGNC NCBI Gene Taxon

2 new papers in 30 daysSee all 9 papers on BARD1

At a glance

The findings reach cells, none yet in people. 1 lab in 1 country.

None of its findings points the other way.

1 lab in 1 country

Funders: Korea Institute of Radiological & Medical Sciences and 1 more

Human trial1
Humans4
Animals1
Cells2

Interventions

1

Metformin

upin human cells1

1 study

Metformin increases BARD1 in human cells during irradiation and aging in HAECs.
“metformin increased BRCA1-associated RING domain protein 1 (BARD1) and RAD51 expression in both aging and IR-exposed cells”
Cellsduring irradiation and aging in HAECs
Metformin alleviates ionizing radiation-induced senescence by restoring BARD1-mediated DNA repair in human aortic endothelial cells
Experimental gerontologyJan 24, 2022

More on Metformin

Effects

1

Cellular senescence

is required forin human cells1

1 study

BARD1 is required for cellular senescence in human cells (metformin-mediated inhibition of endothelial senescence in HAECs).
“BARD1 knockdown confirmed its critical role in metformin-mediated inhibition of endothelial senescence”
Cellsmetformin-mediated inhibition of endothelial senescence in HAECs
Metformin alleviates ionizing radiation-induced senescence by restoring BARD1-mediated DNA repair in human aortic endothelial cells
Experimental gerontologyJan 24, 2022

More on Cellular senescence

Latest

6 papers in 12 months

Obstetrical & Gynecological SurveyNov 5

Comment on “Patient-Centered Approach to Surgical Prevention of Ovarian Cancer: A Nonrandomized Clinical Trial”

Trial in 334 peopleOvarian cancer

Frontiers in OncologyOct 30

Case Report: BARD1 p.Val507Met in Two Relatives With ER-Positive Breast Cancer: Cascade Testing and Exploratory Longitudinal cfDNA Dynamics

Accepted, not yet published: case seriesBiomarkers

European Journal of Breast HealthJun 19

Hereditary Cancer Genetic Testing for All? A Retrospective Analysis on Genetic Mutations Found in Individuals Not Meeting NCCN® Guidelines

Cross-sectional study of 8,100 peopleInterventions

NPJ Breast CancerMar 19

Comprehensive genomic analysis of non-BRCA familial breast cancer in an Arab population

Genetic association study of 6,000 peopleBreast cancer

Journal of NanobiotechnologyFeb 27

Fisetin-loaded nanoparticles as a novel approach for cholesterol regulation in hypercholesterolemia: targeting the ASGR1-mediated mTORC1/AMPK pathway

Experiments in miceFisetin

The Breast JournalJan 22

Tyrer-Cuzick Lifetime Risk Is Not Associated With Non-BRCA1/2 Pathogenic Variants for Breast Carcinoma

Genetic association study of 964 peopleBiomarkers

Experimental GerontologyJan 28

Metformin alleviates ionizing radiation-induced senescence by restoring BARD1-mediated DNA repair in human aortic endothelial cells

Experiments in human cellsMetformin

PLOS OneAug 5

Patients experiencing statin-induced myalgia exhibit a unique program of skeletal muscle gene expression following statin re-challenge

Case-control study in peopleStatins

Cell ReportsJun 1

The Histone Variant MacroH2A1 Is a BRCA1 Ubiquitin Ligase Substrate

Experiments in human cellsBRCA1