azot

1. azot shortens lifespan in flies.

   “ahuizotl (azot) mutants accumulate unfit cells during adulthood and after physical insults in the brain and other epithelial tissues, showing a decrease in organismal lifespan.”

   Reviewshown by mutant

   Azot expression in the Drosophila gut modulates organismal lifespan

   Communicative & integrative biology·Dec 28, 2022

2. azot extends lifespan in flies.

   “flies carrying three functional copies of the gene, unfit cell culling seems to be more efficient and show an increase in lifespan.”

   Reviewshown by extra functional gene copy (three copies)

   Azot expression in the Drosophila gut modulates organismal lifespan

   Communicative & integrative biology·Dec 28, 2022

1. azot has no effect on loser cell elimination in flies.

   “Azot is not required for loser cell elimination in this context.”

   Model organismsoptic lobes

   Longitudinal analysis of Flower-dependent cell competition fitness markers in Drosophila melanogaster

   bioRxiv (Cold Spring Harbor Laboratory)·Mar 27, 2024Preprint

1. azot is associated with cells undergoing apoptosis in flies (>50%).

   “over 50% of cells undergoing apoptosis at any given time point are positive for the loser markers Fwe LB and Azot.”

   Model organismsoptic lobes

   Longitudinal analysis of Flower-dependent cell competition fitness markers in Drosophila melanogaster

   bioRxiv (Cold Spring Harbor Laboratory)·Mar 27, 2024Preprint

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