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AGO2

Gene

1 paper2 findings

NCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funder: National Institute of Neurological Disorders and Stroke
  • 2 of 2 findings with company ties
  • Model organisms1

Effects

2

Memory impairment

downin flies1

1 study

  1. AGO2 protects against memory impairment in flies.

    “progressive and age-dependent memory impairment”

    Model organismsin Ago2 mutants

    Activation of transposable elements during aging and neuronal decline in Drosophila

    Nature neuroscience7 Apr 2013

Transposon expression

downin flies1

1 study

  1. AGO2 decreases transposon expression in flies.

    “mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain”

    Model organismsin Ago2 mutantsbrain

    Activation of transposable elements during aging and neuronal decline in Drosophila

    Nature neuroscience7 Apr 2013

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