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ACSL6

Gene

1 paper2 findings

HGNCNCBI GeneTaxon

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Includes the processes named after it and trials of drugs aimed at it.

  • 1 lab in 1 country
  • Funders: East Carolina University and 3 more
  • Animals1

Effects

2

Neuroinflammation

downin mice1

1 study

  1. ACSL6 protects against neuroinflammation in mice.

    “With age, the Acsl6-/- cerebellum became inflamed and gliotic.”

    Animalsaging in Acsl6-/- micecerebellum

    Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging

    JCI insight8 Jun 2021

Working spatial memory

upin mice1

1 study

  1. ACSL6 improves working spatial memory in mice.

    “Across the life span, Acsl6-/- mice exhibited hyperlocomotion, impairments in working spatial memory”

    Animalsshown by Acsl6-/- knockout across the life span

    Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging

    JCI insight8 Jun 2021

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