5XFAD

2 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

A gene’s or a process’s line counts the gene with the processes named after it, as NLRP3 with the NLRP3 inflammasome, and the trials of drugs aimed at it.

2 independent labs in 2 countries

Funders: National Institute on Aging and 1 more
1 of 2 findings with company ties

Animals2

Effects

Behavioral hearing detection

no changein mice1

1 study

5XFAD has no effect on behavioral hearing detection in mice.
“There were no differences between 5xFAD mutant and WT mice.”
Animalsin 5xFAD versus WT control mice
Differences in hearing across the lifespan in two strains of Alzheimer's mouse models as measured using behavioral and physiological techniques
Hearing research29 Jan 2026

Walking distance

upin mice1

1 study

5XFAD increases walking distance in mice.
“At 14 months of age, female 5xFAD mice showed a significant increase in walking distance compared to their 6‐month‐old counterparts, indicating a progressive hyperactivity phenotype with aging.”
Animalscompared to 6-month-old counterpartsfemales
Investigating Hyperactivity in Alzheimer's Disease: Genetic and Dietary Influences in AD‐BXD Mice
AAIC 2025 abstract23 Dec 2025