Tissue calcification

1. Ammonium nitrate decreases tissue calcification in klotho-hypomorphic (kl/kl) mice.

   “decreased calcification of trachea, lung, kidney, stomach, heart and vessels”

   Animalsin klotho-hypomorphic (kl/kl) micetrachea, lung, kidney, stomach, heart, vessels0.28 M in drinking water

   Partial Reversal of Tissue Calcification and Extension of Life Span following Ammonium Nitrate Treatment of Klotho-Deficient Mice

   Kidney & blood pressure research·Feb 16, 2016

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1. Acetazolamide decreases tissue calcification in mice (kl/kl mice) (almost completely reversed).

   “almost completely reversed the calcifications in trachea, lung, kidney, stomach, intestine, and vascular tissues”

   Animalskl/kl micetrachea, lung, kidney, stomach, intestine and vascular tissues0.8 g/l in drinking water

   Acetazolamide sensitive tissue calcification and aging of klotho-hypomorphic mice

   Journal of molecular medicine (Berlin, Germany)·Aug 27, 2015

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1. Ammonium chloride prevents tissue calcification in mice (klotho-hypomorphic (kl/kl) mice).

   “NH4Cl treatment in drinking water (0.28 M) prevented soft tissue and vascular calcification”

   Animalsklotho-hypomorphic (kl/kl) micesoft tissue and vasculature0.28 M

   NH4Cl Treatment Prevents Tissue Calcification in Klotho Deficiency

   Journal of the American Society of Nephrology : JASN·Feb 2, 2015

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