Thyroid tumour

1. E2F1 increases thyroid tumour in mice.

   “loss of E2f1 reduces the frequency of pituitary and thyroid tumours”

   Animalsshown by knockout (in Rb1+/- mice)

   Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

   Nature genetics·1 Apr 1998

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1. Rapamycin lowers the risk of thyroid tumour in mice.

   “delay in, but not full blockade of, the development of a range of proliferative lesions, including gastro-intestinal and thyroid tumours”

   Animalsheterozygous germline Pten lossthyroid glandlow dose

   Long-term treatment of cancer-prone germline PTEN mutant mice with low-dose rapamycin extends lifespan and delays tumour development

   The Journal of pathology·31 Oct 2022

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