Systemic apolipoprotein A-II amyloidosis

1. SERPINE1 decreases systemic apolipoprotein A-II amyloidosis in mice.

   “whereas wild-type controls displayed significantly lower amyloid burden and penetrance.”

   Animalsshown by PAI-1 knockout compared with wild-type controls

   Accelerated APOA-II senile amyloidosis in a PAI-1 (plasminogen activator inhibitor 1) knock-out model

   bioRxiv (Cold Spring Harbor Laboratory)·22 Dec 2025Preprint

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