Subsequent fractures

1. Exercise is associated with subsequent fractures in humans.

   “exercise was identified as a protective factor.”

   HumansAfter surgery for a first unilateral fragility hip fracture2 years

   Model estimates further fracture risk after hip fracture surgery

   BMC musculoskeletal disorders·Jul 23, 2026

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1. Subsequent fracture prediction nomogram predicts subsequent fractures in humans (Validation AUC 0.896 (95% CI: 0.832-0.941); C-index 0.861).

   “The 2-year time-dependent AUCs were 0.925 (95% CI: 0.899-0.952) in the development cohort and 0.896 (95% CI: 0.832-0.941) in the temporal validation cohort.”

   HumansTemporal validation cohort after surgery for a first unilateral fragility hip fracture2 yearsn = 415

   Model estimates further fracture risk after hip fracture surgery

   BMC musculoskeletal disorders·Jul 23, 2026

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1. autumn season raises the risk of subsequent fractures in humans (HR 1.790 [95% CI: 1.119, 2.864]; p = 0.015).

   “autumn-indexed fractures (HR 1.790 [95% CI: 1.119, 2.864]; p = 0.015) independently elevated refracture risk.”

   Humans

   Subsequent fracture risk after hip fracture surgery in China: a three-year retrospective cohort study

   BMC geriatrics·Dec 12, 2025

1. Falls raise the risk of subsequent fractures in humans (HR 1.552 [95% CI: 1.089, 2.210]; p = 0.015).

   “recent fall history (HR 1.552 [95% CI: 1.089, 2.210]; p = 0.015)”

   Humans

   Subsequent fracture risk after hip fracture surgery in China: a three-year retrospective cohort study

   BMC geriatrics·Dec 12, 2025

1. Dementia raises the risk of subsequent fractures in humans (HR 1.849 [95% CI: 1.209, 2.828]; p = 0.005).

   “Dementia (HR 1.849 [95% CI: 1.209, 2.828]; p = 0.005)”

   Humans

   Subsequent fracture risk after hip fracture surgery in China: a three-year retrospective cohort study

   BMC geriatrics·Dec 12, 2025

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1. Bisphosphonates raise the risk of subsequent fractures in humans (sHR 1.16; 95% CI 1.11-1.21).

   “higher rates of any subsequent fracture (sHR 1.16; 95% CI 1.11-1.21)”

   Humanspost hip fracture

   The effectiveness of bisphosphonates vs denosumab in people with dementia or frailty post hip fracture: a multi-database cohort study

   Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Dec 7, 2025

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