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Scleroderma-associated interstitial lung disease

Disease

1 paper2 findings

  • Humans1

Associations

2

Telomere length

downin humans1

1 study

  1. Scleroderma-associated interstitial lung disease is associated with telomere length in humans.

    “independent of age, SSc-ILD had significantly shorter telomeres than controls in type II alveolar cells in the lung”

    Humansindependent of agelung

    Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease

    Frontiers in immunology25 Jan 2024

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Cellular senescence

upin humans1

1 study

  1. Scleroderma-associated interstitial lung disease is associated with cellular senescence in humans.

    “markers (GDF15, COMP, and CDKN2A) and pathways (p53) of senescence were significantly increased in SSc-ILD”

    Humansin SSc-ILD lung tissueslung

    Gene expression meta-analysis reveals aging and cellular senescence signatures in scleroderma-associated interstitial lung disease

    Frontiers in immunology25 Jan 2024

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