Progeroid disorders
2 papers
- Animals1
- Cells1
Latest
3 in 12 monthsMolecular Therapy Nucleic Acids
Development of an exon 27-skipping antisense oligonucleotide as a targeted therapy for refractory skin ulcers in Werner syndrome
Experiments in ratsSkin
Aging
Life expectancy and causes of death in classical laminopathic progeroid syndromes: systematic review with individual-patient data synthesis
Systematic review of observational studiesPopulations
Mutation Research Genetic Toxicology and Environmental Mutagenesis
Protective role of Cockayne Syndrome B (CSB) protein in maintaining genome integrity in human cells under oxidative stress
Experiments in human cellsOxidative stress and ROS signalling
Cytogenetic and Genome Research
Molecular Mechanisms of Proliferative Senescence and Genomic Instability in Werner Syndrome and the WRN Gene Network
ReviewDNA damage response
Science China Life Sciences
Counteracting lysosome defects alleviates the cellular senescence of Hutchinson-Gilford progeria syndrome
Experiments in human cellsCellular senescence
bioRxiv
The Accumulation of Progerin Underlies the Loss of Aortic Smooth Muscle Cells in Hutchinson-Gilford Progeria Syndrome
Preprint: experiments in miceLMNA
bioRxiv
HTRA3 protease-chaperone stabilizes cathepsin B for mitochondrial POLG1 depletion in human cell ageing
Preprint: experiments in human cellsProtein folding and chaperones
Nature Communications
Persistent TFIIH binding to non-excised DNA damage causes cell and developmental failure
Experiments in wormsDNA damage response