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Protein farnesyltransferase inhibitor

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Dental and Craniofacial Research and 4 more
  • Animals1

Outcomes

1

Aberrant nuclear morphology

downin mouse cells1

1 study

  1. Protein farnesyltransferase inhibitor decreases aberrant nuclear morphology in mouse cells.

    “Cultured embryonic fibroblasts from LmnaL648R/L648R mice have aberrant nuclear morphology that is reversible by treatment with a protein farnesyltransferase inhibitor.”

    CellsCultured fibroblasts from LmnaL648R/L648R miceembryonic fibroblast

    Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

    Proceedings of the National Academy of Sciences of the United States of AmericaFeb 25, 2022

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