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Pituitary tumours

Disease

4 papers2 findings

  • Animals4

Upstream

1

E2F1

upin mice1

1 study

  1. E2F1 increases pituitary tumours in mice.

    “Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice”

    Animalsshown by knockout (in Rb1+/- mice)

    Loss of E2F-1 reduces tumorigenesis and extends the lifespan of Rb1(+/-)mice

    Nature genetics1 Apr 1998

More on E2F1

Associations

1

CD-COBS-VAF variant

upin rats1

1 study

  1. CD-COBS-VAF variant raises the risk of pituitary tumours in rats.

    “CD-COBS-VAF rats showed an increase in the incidence of pituitary tumours in males”

    Animalsin CD-COBS-VAF vs CD-COBS ratsmales

    Fat, frail and dying young: survival, body weight and pathology of the Charles River Sprague-Dawley-derived rat prior to and since the introduction of the VAFR variant in 1988

    Human & experimental toxicology1 Mar 1993

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