Osteoporosis risk: aging research evidence

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1

Grip strength

mediatesin humans1

1 study

Grip strength mediates osteoporosis risk in humans.
“Grip strength partially mediated this association.”
HumansPartial mediation of the association between frailty and osteoporosis risk
Higher frailty over time linked to osteoporosis risk
Journal of global healthOct 19, 2026

Trial sponsors

Radius Health
Company1 trialPhase 323 people
Academisch Medisch Centrum - Universiteit van Amsterdam
1 trialPhase 448 people
Odense University Hospital
1 trialPhase 2148 people

Funding

9 grants since 2018

Japan Society for the Promotion of ScienceJP¥26.3mNational Institute on AgingUS$55.1kNational Science FoundationUS$50k

Latest

64 papers in 12 months

Journal of Global HealthYesterday

Higher frailty over time linked to osteoporosis risk

Compared with low-frailty groups, higher-frailty groups generally faced greater osteoporosis risk in three observational cohorts of adults aged 50 and older.Compared with low-frailty groups, higher-frailty groups generally faced greater osteoporosis risk in three observational cohorts of adults aged 50 and older.

Cohort · 57,940 peopleOsteoporosis

Paper

HealthcareOct 16

Real-World Validation of an AI-Based Opportunistic Osteoporosis Risk Stratification Tool Using Chest Radiographs in a Male-Predominant Cohort

Cross-sectional study of 2,336 peopleOsteoporosis

Paper

iScienceOct 14

Repeated blood samples better predicted osteoporosis risk

A model using repeated blood samples scored 0.67–0.76 at distinguishing future osteoporosis cases from controls, versus 0.57–0.63 for single-sample models.A model using repeated blood samples scored 0.67–0.76 at distinguishing future osteoporosis cases from controls, versus 0.57–0.63 for single-sample models.

Case-control · 198 peopleOsteoporosis

Paper

BMC GeriatricsOct 12

Development and validation of a machine learning model for screening individuals at high risk of self-reported osteoporosis among community-dwelling older adults: a cross-sectional study

Cross-sectional study of 1,896 peopleOsteoporosis

Paper

Journal of Orthopaedic SurgeryOct 11

Glaucoma eye-drop groups differed in osteoporosis risk

Osteoporosis was diagnosed in 13.3% of patients prescribed drops such as latanoprost, compared with 8.9% prescribed drops such as pilocarpine.Osteoporosis was diagnosed in 13.3% of patients prescribed drops such as latanoprost, compared with 8.9% prescribed drops such as pilocarpine.

Cohort study of 6,743 peoplePrimary open-angle glaucoma

Paper

Research SquareOct 9

Primary Care Engagement and Osteoporosis Fracture Risk: Findings from a Community Health Fair Screening Initiative

Preprint: cross-sectional study of 132 peopleMajor osteoporotic fractures

Paper

Internal and Emergency MedicineOct 2

ARNI links to lower osteoporosis risk in heart failure

Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.Patients taking an ARNI had an adjusted hazard ratio of 0.6 for osteoporosis compared with those taking an ACE inhibitor.

Cohort study of 12,808 peopleOsteoporosis

Paper

Preventive MedicineOct 1

Poor sleep patterns are linked to higher osteoporosis risk

In 63,083 UK adults, short sleep had a hazard ratio of 1.16, irregular sleep 1.21, and low sleep efficiency 1.23 for incident osteoporosis.In 63,083 UK adults, short sleep had a hazard ratio of 1.16, irregular sleep 1.21, and low sleep efficiency 1.23 for incident osteoporosis.

Cohort study of 63,083 peopleOsteoporosis

Paper

Journal of Research in Medical SciencesSep 30